Our human body consists of trillions of cells. Each of them serving a specific function. As with all complex ‘machines‘, at times our body breaks down of its own accord or due to external stimuli. When that happens – the road to recovery can be challenging. And it can be a slow, long and painful process, sometimes even discouraging. The question “How to Be Running without Knee Pain?” is looking for answers which the REJUVENATOR PLATINUM ***** EXTERNAL HEART machine delivers: One device – many applications with many benefits some of which may seem out of this world. It is the most luxurious and most effective multi-function intermittent vacuum therapy device available today, combined with functions of pressotherapy lymphatic drainage, as well as photobiostimulation.

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Improved arterial perfusion and capillarisation
Prof. J.P. Belgrado at the University of Brussels, Institute Research Lymphologiegue in Belgium has done research what could be measured. He found that different frequencies cause different physiological reactions. On an arterial level thermography has shown an increase of arterial perfusion and capillarisation. On a venous level Doppler / Duplex Sonography has shown an increase of venous backflow. Impedance measurement, sonography and lymphoflouroscopy confirmed a lymphatic drainage. The Rejuvenator-Platinum provides automated preset programs for different purposes and benefits by combining both methods. Prof. Dr. med. Strauß, Angiology at the Dominikus Hospital in Düsseldorf, Germany noted an increase of acral pulse during the IVT treatment of chronic critical ischaemia with a 61 years old patient.

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Lymph capillaries - your most important network
The lymph capillaries are very fine vessels that shape a tremendous network throughout the human body. They begin as blind sacs in the gaps between the cells and carry the leaked tissue fluid along with the cell debris. The lymph flows through the lymph nodes that filter it of foreign particles like virus and bacteria and ultimately returns to the bloodstream.

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The impact of IVT on Nitric Oxide (NO) release:
The medical grade version of the Rejuvenator-Platinum has shown that nerve impluses and shear forces are provoked in every IVT application.
- Neuronal stimulation of endothelial cells via Vacumed (the medical grade version of the Rejuvenator-Platinum) was scientifically confirmed by Prof. Orlietsky from Moscow at the IVT Symposium 2016 in Barcelone, Spain.
- Shearforces in the entire interstitium lead to the formation of collateral vessels. It is a known effect of the IVT.

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Lymph vessels are the channels of the lymph
Lymph travels throughout the body via dedicated highways called lymphatic vessels. All lymph vessels lead to lymph nodes. Similar to arteries or veins that carry blood throughout the human body, lymph vessels are distinct. The flow of lymph is much slower than the flow of blood as lymph has no pump (the heart). Therefore lymph has to be flown. Lymph vessels surround each organ and make a special meshwork that wraps the skin. When the lymph vessels start very tiny they are called the initial lymphatic. Over seventy percent of the initial lymphatics are under or in the skin. The structure of the initial lymphatic is a one cell thick layer. Collagen and elastin fibers enforce those cells within the connective tissue and assist to keep them in place. The filaments transform the wall of the initial lymphatic and opens it up once the pressure within the interstitial zone rises due to a buildup of fluid, or stretching of the skin. When the interstitial fluid then flows in and starts to move along the channel it is called lymph. The lymph system filters between two and three litres of lymph per day. This is crucial because it helps to eliminate proteins that are too big to return through the capillary wall. (Guyton and Hall, Human Physiology and Mechanisms of Disease, sixth edition, W.B Saunders Company, Philadelphia, 1997, page 139). The spaces that open in the initial lymphatic are four to six times larger than the gaps in the capillaries. To avoid swelling or edema removing protein is important because they draw water to themselves, so excess protein in the interstitial spaces has to be prevented. The lymph vessels also serve cleaning by collecting waste products, viruses, dead cells, bacteria, fats, inorganic substances, and water. After the lymph has entered the initial lymphatic, the lymph moves into the pre-collector which is a larger vessel, and then into even larger collectors, the diameter of which ranges from 100 to 600 microns. To ensure that the lymph only moves in one direction these vessels possess one way valves every 6- 20 mm. Around 4 to 5 afferent vessels transport lymph towards the lymph nodes, they open on the convex surface of the lymph node.

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IVT relevant in angiology and phlebology:
Since different treatment methods promote different reflexes during intermittent vacuum therapy, IVT can be used to trigger various specific responses.An extension of the normal pressure stages is used to stimulate arterial perfusion. An extension of the negative pressure phases is used to increase backflow of venous blood and lymph. (Goswami N et al., 2008) "Past Protocols and Technical Consideration for Experimental Design".

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The remarkable mission of lymph nodes
There are between 400-700 almost kidney-shaped lymph nodes in the human body, half of which are positioned in the abdomen, and the rest in the neck, and the size of which can range from the head of a pin to an olive. The lymph nodes have the form of trabeculae and are wrapped in a fibrous capsule that goes deep down into the tissue. The reticular network surrounds the lymph nodes which mainly consist of a vast aggregation of lymphocytes in the form of macrophages and follicles. Its concave shaped hilum shows an artery, nerves, a vein, and one efferent vessel. The primary task of lymph nodes is to filter and clean the lymph. The lymph nodes produce various kinds of lymphocytes. Lymphocytes eliminate harmful substances within the human body, and represent a major part of the immune system. The lymph nodes reabsorb about fourty percent of the liquid content of the lymph. This makes the lymph much thicker. Because of this thickening and the filtering process, the lymph nodes cause the biggest resistance to the flow of lymph. In fact the lymph nodes stand for about 15 times more resistance than the lymph vessels themselves. Lymphatic drainage can help overcome this resistance in lymph flow.

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The effects of alternating positive and negative pressure:
The negative pressure phase invokes capillary dilation and capillarization. The physiological response is an improvement of blood circulation in the periphery and musculature (micro perfusion) and an infiltration of venous blood and lymphatic liquid. The positive pressure phase promotes venous back flow and improved lymph flow. By alternating both - positive and negative pressure - the total flow increases, neurons get stimulated, more oxygen gets into the cells and it increases and protects capillarization.

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Lymph vessels are the channels of the lymph
Lymph travels throughout the body via dedicated highways called lymphatic vessels. All lymph vessels lead to lymph nodes. Similar to arteries or veins that carry blood throughout the human body, lymph vessels are distinct. The flow of lymph is much slower than the flow of blood as lymph has no pump (the heart). Therefore lymph has to be flown. Lymph vessels surround each organ and make a special meshwork that wraps the skin. When the lymph vessels start very tiny they are called the initial lymphatic. Over seventy percent of the initial lymphatics are under or in the skin. The structure of the initial lymphatic is a one cell thick layer. Collagen and elastin fibers enforce those cells within the connective tissue and assist to keep them in place. The filaments transform the wall of the initial lymphatic and opens it up once the pressure within the interstitial zone rises due to a buildup of fluid, or stretching of the skin. When the interstitial fluid then flows in and starts to move along the channel it is called lymph. The lymph system filters between two and three litres of lymph per day. This is crucial because it helps to eliminate proteins that are too big to return through the capillary wall. (Guyton and Hall, Human Physiology and Mechanisms of Disease, sixth edition, W.B Saunders Company, Philadelphia, 1997, page 139). The spaces that open in the initial lymphatic are four to six times larger than the gaps in the capillaries. To avoid swelling or edema removing protein is important because they draw water to themselves, so excess protein in the interstitial spaces has to be prevented. The lymph vessels also serve cleaning by collecting waste products, viruses, dead cells, bacteria, fats, inorganic substances, and water. After the lymph has entered the initial lymphatic, the lymph moves into the pre-collector which is a larger vessel, and then into even larger collectors, the diameter of which ranges from 100 to 600 microns. To ensure that the lymph only moves in one direction these vessels possess one way valves every 6- 20 mm. Around 4 to 5 afferent vessels transport lymph towards the lymph nodes, they open on the convex surface of the lymph node.
